HowXenopus LaevisReplicates DNA Reliably even though Its Origins of Replication are Located and Initiated Stochastically
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How Xenopus laevis replicates DNA reliably even though its origins of replication are located and initiated stochastically.
DNA replication in Xenopus laevis is extremely reliable, failing to complete before cell division no more than once in 10 000 times; yet replication origin sites are located and initiated stochastically. Using a model based on 1D theories of nucleation and growth and using concepts from extreme-value statistics, we derive the distribution of replication times given a particular initiation funct...
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15 صفحه اولReplication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells.
The spatial organization of replicons into clusters is believed to be of critical importance for genome duplication in higher eukaryotes, but its functional organization still remains to be fully clarified. The coordinated activation of origins is insufficient on its own to account for a timely completion of genome duplication when interorigin distances vary significantly and fork velocities ar...
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ژورنال
عنوان ژورنال: Physical Review Letters
سال: 2007
ISSN: 0031-9007,1079-7114
DOI: 10.1103/physrevlett.98.098105